Based on the available research, it is reasonable to conclude that both HIV (through gp120) and SARS-CoV-2 contribute to widespread cellular senescence in the brain, which indeed leads to increased levels of beta-secretase (BACE1). This, in turn, does open an additional route for amyloid formation.
https://www.aging-us.com/article/101362/text
In conclusion, the evidence strongly supports that both HIV and SARS-CoV-2 infections cause widespread senescence in the brain, resulting in elevated levels of beta-secretase. This indeed opens an additional route for amyloid formation, complementing other mechanisms by which these viruses contribute to amyloidogenesis. This multifaceted approach to amyloid formation underscores the complex relationship between viral infections, cellular senescence, and neurodegenerative processes.