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SARS-COV-2 Spike Protein causes prionlike deseases

Based on the additional search results provided, the key information about the “spike532” sequence and its relation to prion protein biogenesis is: The spike532 sequence refers to a specific region within the SARS-CoV-2 spike protein that has been identified as having prion-like properties[2]. Specifically, the search results indicate that the spike532 sequence contains signal sequences […]

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PrP aggregation can be seeded by pre-formed recombinant PrP amyloid fibrils without the replication of infectious prions

However, in studies described here, we show that inoculation of recPrP fibrils does not cause TSE disease, but, instead, seeds the formation of PrP amyloid plaques in PrP-P101L knock-in transgenic mice (101LL). Importantly, both WT-recPrP fibrils and 101L-recPrP fibrils can seed plaque formation, indicating that the fibrillar conformation, and not the primary sequence of PrP

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Welcome to WordPress. This is your first post. Edit or delete it, then start writing!Welcome to WordPress. This is your first post. Edit or delete it, then start writing!Welcome to WordPress. This is your first post. Edit or delete it, then start writing!Welcome to WordPress. This is your first post. Edit or delete it, thenWelcome

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Welcome to WordPress. This is your first post. Edit or delete it, then start writing!Welcome to WordPress. This is your first post. Edit or delete it, then start writing!Welcome to WordPress. This is your first post. Edit or delete it, then start writing!Welcome to WordPress. This is your first post. Edit or delete it, then

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