The article from Future Virology, authored by J Gerlach and AM Baig, discusses the effects of COVID-19 and vaccination on the human immune system, particularly focusing on cases of lymphopenia and autoimmunity. The study explores the possibility that some individuals may be more prone to developing an immune response to self-antigens after COVID-19 infection and […]
Based on the additional search results provided, the key information about the “spike532” sequence and its relation to prion protein biogenesis is: The spike532 sequence refers to a specific region within the SARS-CoV-2 spike protein that has been identified as having prion-like properties[2]. Specifically, the search results indicate that the spike532 sequence contains signal sequences
SARS-COV-2 Spike Protein causes prionlike deseases Read More »
However, in studies described here, we show that inoculation of recPrP fibrils does not cause TSE disease, but, instead, seeds the formation of PrP amyloid plaques in PrP-P101L knock-in transgenic mice (101LL). Importantly, both WT-recPrP fibrils and 101L-recPrP fibrils can seed plaque formation, indicating that the fibrillar conformation, and not the primary sequence of PrP
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